李荣，教授

研究方向：类风湿关节炎发病机制；类风湿关节炎药物治疗机制

电子邮箱：lirong@ahmu.edu.cn

办公室：知行楼B1105

教育经历：

(1) 2007/09-2010/06，维多利亚老品牌vic3308，药学科学学院，博士

(2) 2003/09-2006/06，维多利亚老品牌vic3308，药学科学学院，硕士

(3) 1997/09-2001/06，山东大学，维多利亚老品牌vic3308，学士

工作经历：

(1) 2018/01至今，维多利亚老品牌vic3308，药学科学学院，教授

(2) 2011/09-2017/12，维多利亚老品牌vic3308，药学科学学院，副教授

(3) 2006/09-2011/08，维多利亚老品牌vic3308，药学科学学院，讲师

(4) 2001/07-2006/08，维多利亚老品牌vic3308，药学科学学院，助教

学术荣誉：

2024/01，安徽省教育厅“学科（专业）带头人培育人选”

2013/03，维多利亚老品牌vic3308“中青年学术技术带头人”

科研项目：

（1）安徽省教育厅，高校中青年教师培养行动“学科（专业）带头人培育项目”，DTR2023010，AQP1调控β-catenin/NLRP3炎症小体通路介导的FLS焦亡在类风湿关节炎发病机制中的研究，2024.01-2026.12，10万元，在研，主持

（2）维多利亚老品牌vic3308，科研水平提升计划项目，2022xkjT008，c-Jun/AQP1/Beclin1轴介导FLS自噬上调促进类风湿关节炎滑膜增生和滑膜炎症的机制研究，2023.01-2025.12，30万元，在研，主持

（3）安徽省教育厅，高校与合肥综合性国家科学中心协同创新项目，GXXT-2022-063，水通道蛋白1通过诱导自噬促进类风湿关节炎成纤维样滑膜细胞增殖和炎症的机制研究及靶向药物发现，2023.01-2024.12，50万元，结题，主持

（4）国家自然科学基金委员会，面上项目，81972040，水通道蛋白1通过Wnt/β-catenin通路调控FLS活化参与类风湿关节炎发病的机制研究，2020.01-2023.12，55万元，结题，主持

（5）安徽省教育厅，高校优秀青年人才支持计划重点项目，gxyqZD2016045，水通道蛋白4参与类风湿关节炎关节软骨损伤的机制和功能研究，2016.01-2018.12，6万元，结题，主持

（6）国家自然科学基金委员会，青年科学基金项目，81102273，Hedgehog-GLi1信号通路在类风湿关节炎关节软骨损伤和修复中的作用及机制研究，2012.01-2014.12，24万元，结题，主持

教学项目：

安徽省教育厅，高等学校省级质量工程项目，2022xxkc056，药物化学线下课程，2023.04-2025.04，3万元，在研，主持

发表论文情况：

1. Zhang, Man-yu#; Wang, Meng-qing#; Huang, Yan; Gu, Sheng-long; Zhou, Meng-yuan; Xu, Ze-shan; Li, Ling-ling; Lv, Min; Cai, Li*; Li, Rong*. Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-alpha-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats.Inflammation Research,2025, 74(1): 12.

2. Huang, Yan#; Zhou, Meng-yuan#; Li, Ling-ling; Lv, Min; Xu, Ze-shan; Wu, Xin-jie; Gu, Sheng-long; Zhang, Man-yu; Cai, Li*; Li, Rong*. Bacopaside I, acting as an aquaporin 1 inhibitor, ameliorates rheumatoid arthritis via suppressing aquaporin 1-mediated autophagy.Phytomedicine,2025, 138: 156444.

3. Gu, Sheng-long#; Liu, Xue-song#; Xu, Ze-shan; Li, Ling-ling; Wu, Xin-jie; Li, Fei-long; Huang, Yan; Ran, Xiang*; Li, Rong*. Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis.International Immunopharmacology,2025, 148: 114179.

4. Jiang, Fei#; Wang, Meng-qing#; Zhang, Man-yu; Gu, Sheng-long; Xie, Ya-wen; Huang, Yan; Zhou, Meng-yuan; Li, Fei-long; Yang, Yu-chen; Zhang, Pei-pei; Liu, Xue-song*; Li, Rong*. CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway.International Immunopharmacology,2024, 131: 111850.

5. Liu, Fang-yuan#; Wang, Meng-qing#; Liu, Ming-ming#; Li, Tao; Wang, Xiao-hua; Jiang, Fei; Wu, Xin-jie; Cheng, Juan; Cai, Li*; Li, Rong*. Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/beta-catenin pathway.Phytomedicine,2023, 116: 154857.

6. Cai, Li#; Meng, Bo#; Jiang, Fei#; Shu, Wen-hao; Wang, Xiao-hua; Wang, Meng-qing; Wu, Xin-jie; Hu, Ming-wang; Yang, Yu-chen; Ran, Xiang*; Li, Rong*. Novel HIF-1alpha Inhibitor AMSP-30m Mitigates the Pathogenic Cellular Behaviors of Hypoxia-Stimulated Fibroblast-Like Synoviocytes and Alleviates Collagen-Induced Arthritis in Rats via Inhibiting Sonic Hedgehog Pathway.Inflammation,2023, 46(6): 2289-2305.

7. Cai, Li#; Zong, Pan#; Zhou, Meng-yuan; Liu, Fang-yuan; Meng, Bo; Liu, Ming-ming*; Li, Zeng*; Li, Rong*. 7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/beta-catenin signaling pathway.Phytomedicine,2022, 94: 153841.

8. Cai, Li#; Zhou, Meng-yuan#; Hu, Shuang#; Liu, Fang-yuan; Wang, Meng-qing; Wang, Xiao-hua; Jiang, Fei; Feng, Xiao-wen; Liu, Xue-song; Li, Rong*. Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/beta-Catenin Signaling Pathway.American Journal of Chinese Medicine,2022, 50(7): 1945-1962.

9. Zhou, Meng-yuan#; Cai, Li#; Feng, Xiao-wen; Mu, Yu-rong; Meng, Bo; Liu, Fang-yuan; Li, Rong*. Lentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-alpha-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/beta-Catenin Signaling Pathway.Journal of Inflammation Research,2021, 14: 1945-1957.

10. Zhang, Zi-hao#; Qiao, Yu#; Yang, Li#; Chen, Zu-wang; Li, Tao; Gu, Ming-zhen; Li, Chong; Liu, Ming-ming*; Li, Rong*. Kaempferol 3-O-gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF-beta/ALK5/Smad signaling pathway.Phytotherapy Research,2021, 35(11): 6310-6323.