王汀,教授

研究方向：疫苗佐剂传递系统

电子邮箱：twangcn@ahmu.edu.cn

办公室：知行楼B1401

教育经历：

(1) 2015/09-2016/07中国科学技术大学生命科学院，高级访问学者

(2) 2011/09-2016/06， 沈阳药科大学，维多利亚老品牌vic3308，博士

(3) 2007/09-2011/06， 安徽中医学院，维多利亚老品牌vic3308，硕士

(4) 2007/09-2011/06， 安徽中医学院，维多利亚老品牌vic3308，学士

工作经历：

(1) 2014/11至今，维多利亚老品牌vic3308，维多利亚老品牌vic3308，教授

(2) 2012/06-2014/11，维多利亚老品牌vic3308，维多利亚老品牌vic3308，副教授

(3) 2007/07-2012/06， 济宁医学院， 维多利亚老品牌vic3308， 副教授

(4) 1995/07-1999/08， 安徽省立医院， 药剂科， 药师

科研项目：

1.2018年度省学术和技术带头人后备人选科研活动经费资助项目（安徽省人力资源与社会保障厅）：被覆磷脂双分子层的铝纳米粒：一种新型疫苗佐剂-传递系统，2018H173，4万元，2018.01.01-2019.12.31。

2.2017年度安徽省转化医学研究院科研基金项目，构建新型纳米复合材料并评价其在龋齿预防和浅龋自修复中的效果（B类），2017zhyx19（合作单位主持人）

3.安徽省2016教育厅高校自然科学研究重大项目(主持人)：一种适于控温链的粘膜疫苗佐剂-双途径传递系统，资助额20万元，项目编号：KJ2016SD28，研究时间：2016.01-2018.12。

4.国家自然科学基金项目(主持人)：双功能分子修饰脂质体构建疫苗脱冷链靶向载体-佐剂系统，项目编号81273452/H3008 (安医大项目编号0601057201)，资助额16万，研究时间2013.1-2013.12。

5.山东省自然科学基金项目(主持人)：新型脂质卷口服疫苗载体-佐剂系统及其免疫诱导机理研究，项目编号ZR2010HL067，资助额3万，研究时间2011.01-2013.12。

发表论文情况：

1.Gao Y, Wang N, Qi Y, Wang X, Zhang K, Zhang Y, Cao Y, Zang T, Wang T. The aluminum nanoparticle-encircled SQ-in-water emulsions (ANSWE) as a vaccine adjuvant-delivery system (VADS) for developing robust mucosal subunit vaccines. Biomater Adv. 2025 Jan;166:214076. doi: 10.1016/j.bioadv.2024.214076. Epub 2024 Oct 23.

2.Wang N, Wang C, Wei C, Chen M, Gao Y, Zhang Y, Wang T. Constructing the cGAMP-Aluminum Nanoparticles as a Vaccine Adjuvant-Delivery System (VADS) for Developing the Efficient Pulmonary COVID-19 Subunit Vaccines. Adv Healthc Mater. 2024 Dec;13(32):e2401650. doi: 10.1002/adhm.202401650. Epub 2024 Sep 25.

3.Wang N, Wang T. Innovative translational platforms for rapid developing clinical vaccines against COVID-19 and other infectious disease. Biotechnol J. 2024 Feb;19(2):e2300658. doi: 10.1002/biot.202300658.

4.Jiale Li, Conghui Li, Hui Zhang, Xiang Gao, Ting Wang*, Zengming Wang* and Aiping Zheng*, Preparation of Azithromycin Amorphous Solid Dispersion by Hot-Melt Extrusion: An Advantageous Technology with Taste Masking and Solubilization Effects, Polymers 2022, 14, 495.

5.Yuanyuan Qi#, Can Wang#, Rui Qian, Minnan Chen, Pingping Jiang, Ting Wang*, Ning Wang*. Loading drugs into liposomes by temperature up-down cycle procedure with controllable results fitting prediction by mathematical and thermodynamic process.Materials Science and Engineering: C, Volume 129, 2021, 112379.

6.Ning Wang#, Chunliu Wei#, Zina Zhang, Ting Liu, Ting Wang*, Aluminum Nanoparticles Acting as a Pulmonary Vaccine Adjuvant-Delivery System (VADS) Able to Safely Elicit Robust Systemic and Mucosal Immunity,Journal of Inorganic and Organometallic Polymers and Materials, 2020, 30: 4203–4217.

7.Ning Wang, Minnan Chen, Ting Wang*. Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization,J Controlled Release, 303 (2019) 130-150.

8.Ning Wang#, Rui Qian#, Ting Liu, Tingni Wu & Ting Wang*, Nanoparticulate Carriers Used as Vaccine Adjuvant Delivery Systems.Critical Reviews™ in Therapeutic Drug Carrier Systems, 36(5):449–484 (2019).

9.Ning Wang#, Changlu Qiu#, Minnan Chen, Ting Liu, Ting Wang*. Covering Aluminum Oxide Nanoparticles with Biocompatible Materials to Efficiently Deliver Subunit Vaccines.Vaccines (Basel). 2019,7(2):1-20.

10.Ning Wang, Xueting Wang, Yuanyuan Zhen, Ning Li, Shaohong Jiang,Ting Wang*, Microneedle arrays fabricated with the aluminum-based cochleates as an effective vaginal vaccine adjuvant-delivery system (VADS) (ChinaNanomedicine2016 Conference abstract),Nanomedicine: Nanotechnology, Biology and Medicine 14(2018)1609-1886.

11.Ning Li#, Ning Wang#, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei,Ting Wang*. Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug.Drug Dev Ind Pharm 44(2018)1966-1974.

12.Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang,Ting Wang*. Combining Different Types of Multifunctional Liposomes Loaded with Ammonia Carbonate to Fabricate Microneedle Arrays as a Vaginal Mucosal Vaccine Adjuvant-Dual Delivery System (VADDS),Journal of Controlled Release 246 (2017) 12–29.

13.Xueting Wang#, Ning Wang#, Ning Li, Yuanyuan Zhen,Ting Wang*. Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems.Human Vaccination Immunotherapy. 12 (8) (2016) 2075-89.

14.Ning Li#, Ning Wang#, Xueting Wang, Yuanyuan Zhen,Ting Wang*. Microneedle arrays delivery of the conventional vaccines based on nonvirulent viruses.Drug Delivery. 23(9) (2016) 3234-3247.

15.Ting Wang* & Ning Wang*. Biocompatible Mater Constructed Microneedle Arrays as a Novel Vaccine Adjuvant- Delivery System for Cutaneous and Mucosal Vaccination.Curr Pharm Des. 21(36) (2015) 5245-55.

16.Yuanyuan Zhen, Ning Wang, Xiaoyu Ma, Biao Wei, Shuqin Li,Ting Wang*. Multifunctional liposomes constituting microneedles induced robust systemic and mucosal immunoresponses against the loaded antigens via oral mucosal vaccination.Vaccine 33 (2015) 4330-4340.

17.Ting Wang*, Yuanyuan Zhen, Xiaoyu Ma, Biao Wei, Ning Wang*. PhospholipidBilayer-Coated Aluminum Nanoparticles as an Effective Vaccine Adjuvant-Delivery System.ACS Applied Materials and Interfaces 2015,7 (12): 6391-6396.

18.Ting Wang*, Yuanyuan Zhen, Xiaoyu Ma, Biao Wei, Shuqin Li, Ning Wang*. Mannosylatedand lipid A-incorporating cationic liposomes constituting microneedle arrays as an effective oral mucosal HBVvaccine applicable in the controlled temperature chain.Colloids and Surfaces B:Biointerfaces126 (2015) 520–530.

19.Ning Wang,Ting Wang*, Meiling Zhang, Ruonan Chen, Ruowen Niu, Yihui Deng*. Mannose derivative and lipid A dually decorated cationic liposomes as an effective cold chain free oral mucosal vaccine adjuvant-delivery system.European Journal Pharmaceutics and Biopharmaceutics 88 (2014) 194–206.

20.Ning Wang,Ting Wang*, Meiling Zhang, Ruonan Chen, Yihui Deng*. Using procedure of emulsification–lyophilization to form lipid A-incorporating cochleates as an effective oral mucosal vaccine adjuvant-delivery system (VADS).International Journal Pharmaceutics 68 (2014) 39–49.

21.Jihui Tang*, Xinqun Wang,Ting Wang, Feihu Chen, Jianping Zhou. In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(L-amino acids) micelles loaded with a novel all-trans retinoic acid derivative.European Journal of Pharmaceutical Sciences. 2014 Jan 23;51:157-64.

22.Ting Wang*, Ning Wang, Hui Song, Jian-An Wang, Xiaonan Xi, Aijun Hao. Preparation ofanhydrous reverse micelle delivery systems to enhance oral bioavailability and antidiabetic efficacy of berberine,European Journal of Pharmaceutical Sciences44 (2011) 127–135.

23.Ting Wang*, Ning Wang, Tongyan Wang, Weiran Sun, Tiefu Li. Preparation of submicronliposomes exhibiting an efficient entrapment for drugs by freeze-drying water-in-oil emulsions.Chemistry and Physics of Lipids 164 (2011) 151–157.

24.Ning Wang,Ting Wang*, Maoling Wang, Aijun Hao, Tiefu Li. Using ultrafiltration to facilitate simultaneous quantification of 5-fluorouracil in mouse plasma and tissues by HPLC.J Liq Chromatogr Relat Technol34 (2011) 2033–2047.

25.Ting Wang*, Ning Wang, Aijun Hao, Xia He, Tiefu Li and Yingjie Deng. Lyophilization ofwater-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery.Eur J Pharm Sci, 39 (2010) 373-379.

26.Ting Wang*, Ning Wang, Yingying Zhang, Wancui Shen, Xingmei Gao, Tiefu Li. Solventinjection-lyophilization of tert-butyl alcohol/water cosolvent systems for the preparation of drug-loaded solid lipid nanoparticles.Colloids Surf B Biointerfaces. 79 (2010) 254-261.

27.Ting Wang*, Ning Wang, Xin Jin, Kai Zhang, and Tiefu Li. A novel procedure forpreparation of submicron liposomes—lyophilization of oil-in-water emulsions.J LiposomeRes, 19 (2009) 231-240.

28.Ning Wang,Ting Wang*, Tiefu Li, Yingjie Deng. Modulation of the physicochemical state of interior agents to prepare controlled release liposomes.Colloids Surf B Biointerfaces 69 (2009) 232–238.

29.Ting Wang*, Ning Wang, Tiefu Li, Yingjie Deng. Freeze-drying of double emulsions toprepare topotecan-entrapping liposomes featuring controlled release.Drug Devel. Industr.Pharm.34 (2008) 427–433.

30.Ting Wang*, Wenxiu Li, Yingjie Deng*. Preparation of submicron unilamellartopotecan-entrapping liposomes.Asian J. Pharm. Sci. 2 (2007) 68-76.

31.Ting Wang*, Yingjie Deng*, Yehui Geng, Zibin Gao, Jianping Zou, Zhixuan Wang.Preparation of submicron unilamellar liposomes by freeze-drying double emulsions.Biochim. Biophys. Acta-Biomembranes1758 (2006) 222–231.

32.Zhixuan Wang, Yingjie Deng, Xiaopeng Zhang,Ting Wang, Fenglan Wu. Development and pharmacokinetics of nimodipine-loaded liposomes.J Pharm Pharmacol 58 (2006) 1289-1294.

33.Zhixuan Wang, Xiaopeng Zhang, Yingjie Deng,Ting Wang. Complexation of hydrophobic drugs with hydroxypropyl-β-cyclodextrin by lyophilization using a tertiary butyl alcohol system,J Inclusion Phenom Macrocyclic Chem 57 (2007) 349-354.

发表专利情况：

1.王汀，王宁.脂质体修饰载体构建的微针阵列疫苗佐剂传递系统，专利号ZL 201410314283.7（授权证书号 第2200959号）授权日期2016.08.24。

2.李铁福，王汀.一种新的脂质体制备方法，专利号ZL 200810229239.0.（授权证书号 第1406429号）。

3.王汀，邓英杰.一种新的脂质体制备方法，专利号ZL 200610074935.X.（授权证书号 第981973号）。