邸磊，校聘副教授

研究方向：中药活性成分鉴定及药理活性机制研究；中药大健康产品研发

电子邮箱：dilei@ahmu.edu.cn

办公室：维多利亚老品牌vic3308 知行楼B1111

教育经历：

(1) 2016/09-2019/06， 中国药科大学，基础医学与临床药学学院，博士

(2) 2009/09-2012/06， 安徽大学，生命科学学院，硕士

(3) 2005/09-2009/06， 安徽大学，生命科学学院，学士

工作经历：

(1) 2019/07至今，维多利亚老品牌vic3308，药学科学学院，校聘副教授

(2) 2012/09-2016/06，中科院昆明植物研究所，研究实习员

科研项目：

（1）企业委托技术开发项目，基于经典中药方剂的药食同源大健康产品开发，101万，2025.01-2027.12

（2）企业委托技术开发项目，天然产物小鼠生殖毒性模型构建，1万，2024.07-2025.06

（3）安徽高校自然科学研究项目，重点项目黄花败酱中新木脂素及其衍生物抗转移性前列腺癌活性研，2021.01-2023.12，主持

发表论文情况：

1. Ren B, Li Y, Di L, Cheng R, Liu L, Li H, Li Y, Tang Z, Yan Y, Lu T, Fu R, Cheng Y, Wu Z. A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT[J]. Chinese Journal of Natural Medicines, 2024, 22(2): 112-126.

2.Li Z, Xu Y, Sun X, Fan Z, Zhou Z, Ren F, Li N, Di L. Novel Iridoid Derivatives Isolated from the Roots ofPatrinia scabra with Potential Anti-Renal Fibrosis Activity In Vitro[J]. Molecules, 2024, 29(18): 4419.

3.Jiang M, Li L, Jin Y, Lu L, Lu Z, Lv W, Wang X, Di L, Liu Z. Derivative spectrophotometry-assisted determination of tryptophan metabolites emerges host and intestinal flora dysregulations during sepsis[J]. Anal Biochem, 2024, 694: 115605.

4.Yang Y, Li N, Wang TM, Di L. Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment[J]. Int J Mol Sci, 2021, 22(19): 10827.

5. Fu R, Han CF, Ni T, Di L, Liu LJ, Lv WC, Bi YR, Jiang N, He Y, Li HM, Wang S, Xie H, Chen BA, Wang XS, Weiss SJ, Lu T, Guo QL, Wu ZQ. A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours[J]. Nat Commun, 2019, 10(1): 3210.

6. Di L, Liu LJ, Yan YM, Fu R, Li Y, Xu Y, Cheng YX, Wu ZQ. Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFbeta/BMP signaling in triple-negative breast cancer[J]. J Exp Clin Cancer Res, 2019, 38(1): 134.

7.Luo Q, Tian L, Di L, Yan YM, Wei XY, Wang XF, Cheng YX. (+/-)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis[J]. Org Lett, 2015, 17(6): 1565-1568.

8.Luo Q, Di L, Dai WF, Lu Q, Yan YM, Yang ZL, Li RT, Cheng YX. Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity[J]. Org Lett, 2015, 17(5): 1110-1113.

9.Di L, Shi YN, Yan YM, Jiang LP, Hou B, Wang XL, Zuo ZL, Chen YB, Yang CP, Cheng YX. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties[J]. RSC Advances, 2015, 5(87): 70985-70991.

10.Dou M, Di L, Zhou LL, Yan YM, Wang XL, Zhou FJ, Yang ZL, Li RT, Hou FF, Cheng YX. Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities[J]. Org Lett, 2014, 16(23): 6064-6067.