王佳佳，讲师

研究方向：肝脏药理学、肠肝轴及肠道菌群研究

电子邮箱: wjj@ahmu.edu.cn

办公室：基础楼405

教育经历：

(1) 2005/09-2010/07 维多利亚老品牌vic3308，维多利亚老品牌vic3308，博士（硕博连读）

(2) 2000/09-2005/07维多利亚老品牌vic3308，维多利亚老品牌vic3308，学士

工作经历：

(1) 2010/09至今 维多利亚老品牌vic3308，药理教研室，讲师

科研项目：

（1）维多利亚老品牌vic3308校基础与临床合作研究提升计划项目：基于靶向代谢组学研究肠道菌群雌激素代谢对NASH致肝纤维化的影响及机制(2021xkjT023)

（2）安徽省高校自然科学基金重点项目：植物雌激素毛蕊异黄酮经雌激素受体介导抗肝纤维化作用及其机制（KJ2016A342） 

（3）安徽省高校自然科学基金重点项目：内质网应激在系统性红斑狼疮免疫调节中的作用（KJ2012A149）

发表论文情况：

1.Yueqin Zhu, Chun Cao, Zihao Li, Zhou Xu, Shishun Qian, Jingrong Zhang, Mengxue Li, Xiaojie Hu, Anqi Zhang, Na Du, Xuesheng Pan, Xinchen Wang, Yancai Sun, Jiajia Wang⁎, Yan Huang⁎. ASIC1a regulates ferroptosis in hepatic stellate cells via the Hippo/Yap-1 pathway in liver fibrosis. Int Immunopharmacol. 2024;143(Pt 1):113226.

2.Jiahui Zhou, Xueping Qi, Na Pan, Wanli Li, Haiming Fang⁎, Jiajia Wang⁎, Sheng Wang⁎. A novel UPLC-ESI-MS assay for fifteen portal estrogens and metabolites detection and application in hepatic fibrosis. Anal Biochem, 2023;671:115158. 

3. Haiming Fang⁎, Tingting Yao, Wanli Li, Na Pan, Hang Xu, Qian Zhao, Yuan Su, Kangwei Xiong, Jiajia Wang⁎. Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study. Frontiers in Microbiology.2023,14:1299816.

4. Kangwei Xiong, Qian Zhao, Wanli Li, Tingting Yao, Yuan Su, Jiajia Wang⁎, Haiming Fang⁎. Comparison of the longterm efficacy and safety of multiple endoscopic rubber band ligations in a single session for varying grades of internal hemorrhoids.  Ir J Med Sci. 2023,192(6):2747-2753.

5. Yaxin Wang, Canyan Wu, Jiahui Zhou, Haiming Fang⁎, Jiajia Wang⁎. Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation. BMC Pharmacology & Toxicology, 2022;23(1):77. 

6. Mengmeng Zhang, Yaxin Wang, Guannan Zhu, Cheng Sun, Jiajia Wang⁎. Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride–induced liver fibrosis in mice. Naunyn Schmiedebergs Arch Pharmacol,2021;394(1):189-204. 

7. Jiajia Wang, Guannan Zhu, Cheng Sun, Kangwei Xiong, Tingting Yao, Yuan Su,  Haiming Fang⁎. TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway. Microb Cell Fact. 2020;19(1):158.

8.Jing Liu, Tan Deng, Yaxin Wang, Mengmeng Zhang, Guannan Zhu, Haiming Fang⁎, Jiajia Wang⁎. Calycosin inhibits intestinal fibrosis on CCD-18Co cells via modulating TGF-β/Smad signaling pathway. Pharmacology. 2019;104:81-89. 

9. Tan Deng, Jing Liu, Mengmeng Zhang, Yaxin Wang, Guannan Zhu, Jiajia Wang⁎.  Inhibition Effect of Phytoestrogen Calycosin on TGF-β -Induced Hepatic Stellate Cells Activation, Proliferation and Migration via Estrogen Receptor β. Canadian Journal of Physiology and Pharmacology, 2018, 96(12):1268-1275. 

10.Haiming Fang*, Lian Fu, Jiajia Wang*. Protocol for fecal microbiota transplantation in inflammatory bowel disease: a systematic review and meta-analysis. BioMed Research International, 2018;8941340.